Synthesis and Characterization of Some New α-Hydroxy-β-acetamido Substituted Tryptamine Derivatives

Abstract

Novel α-Hydroxy-β-acetamido substituted tryptamines were synthesized by the trimolecular condensation between N-Phthalimido-α-hydroxy acetaldehyde, Meldrum’s acid and various substituted indoles followed by aminolysis, and careful deprotection. N-Phthalimido-α-hydroxy acetaldehyde was prepared by the reaction between Phthalimide and Glyoxalic acid followed by direct reduction with hexamine in acetic acid medium.