Electrochemical Studies of Ceftriaxone on Eriochrome Black-T Polymer Film Modified Glassy Carbon Electrode

Abstract

A novel electrochemical method was developed for the determination of ceftriaxone (CFRX) based on the polymerised film of Eriochrome Black-T (EBT) on the surface of glassy carbon electrode (GCE) in phosphate buffer solution (PBS) at pH 2.48 by cyclic voltammetric technique (CV). Cyclic voltammetric studies indicated that CFRX was oxidised irreversibly at high positive potential of 1169 mV at bare GCE, giving rise to a well defined oxidation peak at a potential of 1064 mV at poly(EBT) modified GCE. It was found that the oxidation peak current of CFRX at the modified GCE was greatly improved compared with that at the bare GCE. The effects of scan rate, pH and concentration were examined on poly(EBT) modified GCE. A linear relationship was obtained between the anodic peak current(I_pa) and the CFRX concentration in the range of 0.5X10^-3 to 2.0X10^-3 M with a correlation co-efficient of 0.9805. The proposed method was sensitive and simple. It was successfully employed to determine CFRX in pharmaceutical samples.