Synthesis and Characterization of Chromium (III) Complexes of 4(3H)-quinazolinone derived Schiff base: Antimicrobial and DNA interaction Studies

Abstract

The condensation of 2-benzofuran carboxaldehyde with 3-amino-2-methyl-4(3H)quinazolinone has lead to the isolation of quinolin-4(3H)-one derived Schiff base. The chromium (III) complexes of the ligand were also prepared. Both free ligand and its chromium (III) complexes were characterized by elemental analyses, spectral methods (IR, ¹H-NMR, MS and UV–Vis), magnetic and molar conductance measurements, and thermal studies. The bidentate ligand coordinated to the chromium (III) ion through the lactum oxygen and the azomethine nitrogen of the ligand. All of the compounds were investigated for their antimicrobial activities against the Gram-positive and Gram-negative bacteria and fungi. In addition, the DNA binding and nuclease activities of Chromium (III) complexes were performed.