One Step Biosynthesis of Gold Nanoparticles Using the Leaf Extract of Gymnema sylvestre and Study of Its In-vitro Anticancer Activity on MCF-7 Cell Lines

Authors

  • Sk Nurul Hasan
  • Koushik Paul
  • Aditi Dey
  • Subhankar Manna
  • Somenath Roy
  • Braja Gopal Bag
  • Sourav Mondal

Keywords:

Gymnema sylvestre, green synthesis, gold nanoparticles, MTT assay, anticancer

Abstract

The leaf extract of Gymnema sylvestre has been utilized for the synthesis of gold nanoparticles (AuNPs) at room temperature under a very mild condition without any additional stabilizing or capping agents.  Mostly spherical shaped AuNPs of   9-11 nm average diameters were obtained.   The stabilized gold nanoparticles were characterized by Surface Plasmon Resonance Spectroscopy, DLS, HRTEM, Energy dispersive X-ray spectroscopy, SAED and X-Ray diffraction studies. The antioxidant activity of the leaf extract of Gymnema sylvestre has been studied against a long lived 2,2-diphenylpicrylhydrazyl (DPPH) radical at room temperature.  The in-vitro MTT assay revealed a potent, selective, dose and time dependent anticancer activity of the freshly synthesized AuNPs on MCF-7 breast cancer cell lines and showed IC50 at 30.47 μg/mL.   

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Published

2017-03-31

How to Cite

Sk Nurul Hasan, Koushik Paul, Aditi Dey, Subhankar Manna, Somenath Roy, Braja Gopal Bag, & Sourav Mondal. (2017). One Step Biosynthesis of Gold Nanoparticles Using the Leaf Extract of Gymnema sylvestre and Study of Its In-vitro Anticancer Activity on MCF-7 Cell Lines. International Journal of Research in Chemistry and Environment (IJRCE), 7(2), 1–8. Retrieved from https://ijrce.org/index.php/ijrce/article/view/208

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Articles