Estimation of Urinary Biomarker 8- OHDG in OP Pesticide Sprayers of Krishna and Guntur Districts

Abstract

Organophosphate pesticides can generate reactive oxygen species on DNA (both in the nucleus and mitochondria) causes a number of oxidative DNA lesions, results an oxidized form of guanosine, 8-OHdG. Exposure to pesticides both environmentally and occupationally causes  a range of human health problems. It is estimated, worldwide that nearly 10,000 deaths result annually the use of chemical pesticides, with about three-fourths occurring in developing countries The main objective of the study was to evaluate the biochemical levels of 8-OHdG in spot urinary samples under the exposed OP pesticide sprayers and farm workers.