Preparation, Characterization, Water sorption and Drug Release study of 2-acrylamido-2-methylpropane sulfonic acid (AMPS) based hydrogel

Abstract

A novel biodegradable hydrogel composed of starch, 2-acrylamido-2-methylpropane sulfonic acid (AMPS) and acryl amide(AM) have been  prepared by free radical polymerization method using  N,N^I-methylenebisacrylamide(MBA) as cross-linking agent. The structure, morphology, and thermal nature of hydrogel is investigated by Fourier Transform Infrared (FT-IR) spectroscopy, Scanning Electron Microscopy (SEM) and Thermogravimetric Analysis (TGA) respectively. The swelling and tetracycline release profile of hydrogel is investigated under different parameters. The Swelling study shows that the water uptake property of the hydrogel is dependent on composition of polymer, pH and ionic concentration of the medium. The results of in-vitro drug release experiments shows that the hydrogel has sustained release properties and the release rate depends on the equilibrium swelling ratio of the hydrogels and pH of the medium. The diffusion exponent calculated from empirical equation indicated that the water transport mechanism followed non-Fickian.