Synthesis and characterization of novel Organosilicon (IV) complexes with pyridine dicarboxylic acid and Mercapto pyridine carboxylic acid

Abstract

New Organosilicon (IV) complexes of ligands H₂L_a (Pyridine dicarboxylic acid) and H₂L_b (Mercapto Pyridine carboxylic acid) with R₂SiCl₂ & RSiCl₃ (where R=Me, Et, Ph) were synthesized in the presence of sodium methoxide and triethylamine, respectively. The prepared organosilicon complexes were characterized by analytical, molar conductance and spectroscopic techniques including IR, ¹H, ¹³C and ²⁹Si NMR. On the basis of these studies, the resulting complexes have been proposed to have trigonal bipyramidal and octahedral geometries. The ligands and their organosilicon complexes have been evaluated for in-vitro antimicrobial activity against bacteria (Bacillus subtilis, Staphyllococus aurus, and Escherichia coli) and fungi (Aspergillus Niger and Candida albicans). The complexes were found to be more active than their respective ligands.