Synthesis, Characterization and Antibacterial Activity of Novel Schiff Base Derived From 4-Acetyl-3-Methyl-1-(4’-Methyl- Phenyl)-2-Pyrazolin-5-One and its Transition Metal Complexes

Abstract

The novel Schiff base has been synthesized from 4-acetyl-3-methyl-1-(4’methylphenyl)-2- pyrazolin-5-one with 2-amino-4-phenyl-5-methyl thiazole and was characterized by elemental analysis, mass spectra, 1H NMR spectra, 13C NMR spectra and FT IR spectra. This Schiff base forms complexes of type ML2.2H2O (Where M= Mn, Fe, Co, Ni and Cu) and this complexes were characterized by elemental analysis, Magnetic susceptibility, electrical conductance, electronic spectra, infrared spectra and TGA analysis. All the compounds were tested for their antimicrobial activity. The result indicates that the growth of the tested organism was inhibited by most of the compounds.